Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 5/20 | 0.59 |
| ▸ | NFE2L2 | Q16236 | 8/20 | 0.57 |
| ▸ | TFEB | P19484 | 1/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11538838 | 1.00 | PTGES2 (0.59) | PTGES2NFE2L2TFEBTRPA1KDM4E | |
| SCHEMBL5051063 | 0.87 | PTGES2 (0.48) | PTGES2NFE2L2TFEBKDM4EMAPT | |
| SCHEMBL28811626 | 0.84 | NFE2L2 (0.59) | PTGES2NFE2L2TFEBTRPA1KDM4E | |
| SCHEMBL13802795 | 0.84 | NFE2L2 (0.59) | PTGES2NFE2L2TFEBTRPA1KDM4E | |
| SCHEMBL3778421 | 0.82 | NFE2L2 (0.57) | PTGES2NFE2L2TFEBTRPA1KDM4E | |
| SCHEMBL3778415 | 0.82 | NFE2L2 (0.57) | PTGES2NFE2L2TFEBTRPA1KDM4E | |
| SCHEMBL4019329 | 0.78 | NFE2L2 (0.79) | NFE2L2TFEBTRPA1KDM4ENPC1 | |
| SCHEMBL7915752 | 0.78 | NFE2L2 (0.79) | NFE2L2TFEBTRPA1KDM4ENPC1 | |
| SCHEMBL1603719 | 0.78 | NFE2L2 (0.79) | NFE2L2TFEBTRPA1KDM4ENPC1 | |
| SCHEMBL3161859 | 0.76 | NFE2L2 (0.51) | PTGES2NFE2L2TFEBTRPA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4136180-A | HYPOLIPIDEMIC SUBSTITUTED STYRENESULFONYLUREAS | PFIZER INC. (US) | 1979-01-23 | — | — | US | disclosed |
| US-4062960-A | Hypolipidemic alkenesulfonamides | PFIZER INC. (US) | 1977-12-13 | — | — | US | disclosed |
| US-3983107-A | ARTERIOSCLEROSIS | PFIZER INC. (US) | 1976-09-28 | — | — | US | disclosed |