Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | PIM1 | P11309 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11751799 | 0.81 | PIM1 (0.79) | SMN1; SMN2HTTKDM4EMAPTALDH1A1 | |
| SCHEMBL21434305 | 0.81 | SMN1; SMN2 (0.74) | SMN1; SMN2HTTKDM4EMAPTALDH1A1 | |
| SCHEMBL8793638 | 0.81 | ALOX15 (0.63) | SMN1; SMN2HTTKDM4EMAPTALDH1A1 | |
| SCHEMBL2764709 | 0.81 | TSHR (0.65) | SMN1; SMN2HTTKDM4EMAPTALDH1A1 | |
| SCHEMBL10764354 | 0.81 | ALOX15 (0.63) | SMN1; SMN2HTTKDM4EMAPTALDH1A1 | |
| SCHEMBL10965004 | 0.80 | PIM1 (0.76) | SMN1; SMN2HTTKDM4EMAPTALDH1A1 | |
| SCHEMBL4739564 | 0.77 | PIM1 (0.77) | SMN1; SMN2HTTKDM4EMAPTALDH1A1 | |
| SCHEMBL11744529 | 0.77 | PIM1 (1.00) | SMN1; SMN2HTTKDM4EMAPTALDH1A1 | |
| SCHEMBL11750943 | 0.77 | PIM1 (0.77) | SMN1; SMN2HTTKDM4EMAPTALDH1A1 | |
| SCHEMBL11750697 | 0.77 | PIM1 (0.72) | HTTKDM4EMAPTALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4136182-A | TRIAZOLOPYRIDAZINES USED TO ALLEVIATE BRONCHIAL SPASMS | THE DOW CHEMICAL COMPANY (US) | 1979-01-23 | — | — | US | disclosed |