Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | HTR1B | P28222 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1827264 | 0.90 | MEN1 (0.46) | MEN1KMT2ARAB9AL3MBTL1NISCH | |
| SCHEMBL2092663 | 0.78 | SLC6A2 (0.39) | RAB9ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7059946 | 0.75 | MCHR1 (0.54) | MEN1KMT2ARAB9AL3MBTL1HTR1B | |
| SCHEMBL16789532 | 0.75 | MCHR1 (0.54) | MEN1KMT2ARAB9AL3MBTL1HTR1B | |
| SCHEMBL3554168 | 0.74 | SCD (0.41) | SLC6A2SLC6A4SLC6A3TDP1 | |
| SCHEMBL1828238 | 0.73 | HRH1 (0.40) | RAB9AALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3158944 | 0.72 | SLC6A2 (0.43) | MEN1KMT2ARAB9ANISCHALDH1A1 | |
| SCHEMBL3120094 | 0.72 | MEN1 (0.45) | MEN1KMT2ARAB9AL3MBTL1NISCH | |
| SCHEMBL3174760 | 0.72 | SLC6A4 (0.45) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16902862 | 0.72 | MEN1 (0.51) | MEN1KMT2ARAB9AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4170653-A | Antidepressant naphthyloxy piperidino and pyrrolidino propanol ethers | Ayerst McKenna and Harrison Limited (CA) | 1979-10-09 | — | — | US | disclosed |