Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | FBP1 | P09467 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11540897 | 1.00 | AKR1C3 (0.50) | AKR1C3ALDH1A1TSHRFBP1RECQL | |
| SCHEMBL3778092 | 0.82 | PTGES2 (0.50) | AKR1C3FBP1PTGES2PTGS2AKR1C1 | |
| SCHEMBL3778097 | 0.82 | PTGES2 (0.50) | AKR1C3FBP1PTGES2PTGS2AKR1C1 | |
| SCHEMBL2861584 | 0.81 | AKR1C3 (0.52) | AKR1C3ALDH1A1TSHRFBP1RECQL | |
| SCHEMBL750813 | 0.81 | AKR1C3 (0.52) | AKR1C3ALDH1A1TSHRFBP1RECQL | |
| SCHEMBL5418658 | 0.79 | AKR1C3 (0.50) | AKR1C3ALDH1A1TSHRFBP1RECQL | |
| SCHEMBL28849988 | 0.79 | AKR1C3 (0.50) | AKR1C3ALDH1A1TSHRFBP1RECQL | |
| SCHEMBL5419434 | 0.79 | AKR1C3 (0.50) | AKR1C3ALDH1A1TSHRFBP1RECQL | |
| SCHEMBL4619195 | 0.79 | AKR1C3 (0.50) | AKR1C3ALDH1A1TSHRFBP1RECQL | |
| SCHEMBL28850007 | 0.79 | AKR1C3 (0.50) | AKR1C3ALDH1A1TSHRFBP1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4136180-A | HYPOLIPIDEMIC SUBSTITUTED STYRENESULFONYLUREAS | PFIZER INC. (US) | 1979-01-23 | — | — | US | disclosed |
| US-4062960-A | Hypolipidemic alkenesulfonamides | PFIZER INC. (US) | 1977-12-13 | — | — | US | disclosed |
| US-3983107-A | ARTERIOSCLEROSIS | PFIZER INC. (US) | 1976-09-28 | — | — | US | disclosed |