Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.59 |
| ▸ | CDK9 | P50750 | 1/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.54 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30065871 | 0.84 | EPHX2 (0.54) | GAALMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL27846204 | 0.82 | POLB (0.61) | GAALMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10419324 | 0.82 | GAA (0.68) | GAALMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL29191732 | 0.81 | MEN1 (0.60) | GAALMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL10836155 | 0.81 | GAA (1.00) | GAALMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL29191763 | 0.81 | GAA (0.71) | GAALMNASMN1; SMN2TSHRMAOA | |
| SCHEMBL282531 | 0.81 | SMN1; SMN2 (0.71) | GAALMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL29191736 | 0.80 | NPC1 (0.59) | GAALMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8884482 | 0.79 | SMN1; SMN2 (0.69) | GAALMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL16374950 | 0.78 | SMN1; SMN2 (0.67) | GAASMN1; SMN2ALDH1A1KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4170706-A | Method for preparing the bispicrate salt of 2,3,7,8-tetraazaspiro[4.4]nonane | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1979-10-09 | — | — | US | disclosed |
| US-4170707-A | Method for preparing 3,8-dicarbomethoxy-2,3,7,8-tetraazaspiro[4.4]nona-1,6-diene | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1979-10-09 | — | — | US | disclosed |
| US-4125728-A | Method for preparing 2,3,7,8-tetraazaspiro[4,4]nona-2,7-diene | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1978-11-14 | — | — | US | disclosed |
| US-4066833-A | 2,3,7,8-Tetraazaspiro [4.4]nonane, 2,3,7,8-tetraazaspiro-[4.4]nona-2,7-diene and derivatives | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1978-01-03 | — | — | US | disclosed |