Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA7 | P43166 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11542690 | 0.90 | ALDH1A1 (0.46) | ALDH1A1KDM4EHSD17B10USP2LMNA | |
| SCHEMBL11545605 | 0.85 | ALDH1A1 (0.45) | ALDH1A1KDM4EHSD17B10USP2LMNA | |
| SCHEMBL11542637 | 0.84 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10USP2LMNA | |
| SCHEMBL11542507 | 0.83 | KDM4E (0.58) | ALDH1A1KDM4EHSD17B10USP2LMNA | |
| SCHEMBL11543553 | 0.79 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10USP2LMNA | |
| SCHEMBL11544955 | 0.78 | ALDH1A1 (0.50) | ALDH1A1KDM4EHSD17B10USP2LMNA | |
| SCHEMBL11547756 | 0.78 | ALDH1A1 (0.41) | ALDH1A1KDM4EHSD17B10USP2LMNA | |
| SCHEMBL11543896 | 0.78 | ALDH1A1 (0.73) | ALDH1A1KDM4EHSD17B10USP2LMNA | |
| SCHEMBL11543563 | 0.77 | KDM4E (0.60) | ALDH1A1KDM4EHSD17B10USP2LMNA | |
| SCHEMBL11544254 | 0.77 | KDM4E (0.57) | ALDH1A1KDM4EHSD17B10USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4161531-A | Diuretic and saluretic 5-sulfamoylbenzoic acid derivatives carrying a heterocyclic substituent | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-17 | — | — | US | disclosed |
| US-4118397-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
| US-4093735-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-06 | — | — | US | disclosed |
| US-4010273-A | DIURETICS, SALURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-03-01 | — | — | US | disclosed |