SCHEMBL11544152

SCHEMBL11544152

O=c1[nH]c(=O)c2cc(Cl)cc(Br)c2s1

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.35
CMA1 P23946 1/20 0.35
GSK3B P49841 1/20 0.33
PIM1 P11309 1/20 0.33
PIM2 Q9P1W9 1/20 0.33
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
PGR P06401 1/20 0.30
KDM4E B2RXH2 1/20 0.30
GRIN2D O15399 1/20 0.30
GRIN3B O60391 1/20 0.30
ALDH1A1 P00352 1/20 0.30
GAA P10253 1/20 0.30
GRIN1 Q05586 1/20 0.30
GRIN2A Q12879 1/20 0.30
GRIN2B Q13224 1/20 0.30
GRIN2C Q14957 1/20 0.30
GRIN3A Q8TCU5 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11541524 0.82 GSK3B (0.35) GSK3BPIM1PIM2
SCHEMBL11539575 0.82 GRIN1 (0.39) PARP1CMA1PIM1PIM2PGR
SCHEMBL6644700 0.69 PARP1 (0.42) PARP1GSK3BNPC1RAB9AKDM4E
SCHEMBL2471476 0.69 ERN1 (0.36) ALDH1A1
SCHEMBL7031558 0.68 PARP1 (0.37) PARP1GSK3BNPC1RAB9AKDM4E
SCHEMBL30784338 0.66 NPC1 (0.39) PARP1PIM1PIM2NPC1RAB9A
SCHEMBL11539582 0.64 PARP1 (0.44) PARP1GSK3BPIM1KDM4E
SCHEMBL14094293 0.64 PARP1 (0.46) PARP1KDM4EGRIN2DGRIN3BALDH1A1
SCHEMBL11540764 0.64 PKM (0.35)
SCHEMBL15281526 0.63 GSK3B (0.33) GSK3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4140532-A ORGANIC SILVER SALT, CATALYST, REDUCING AGENT, 2H-1,3-BENZOTHIAZIN-2,4(3H-)DIONE FUJI PHOTO FILM CO., LTD. (JP) 1979-02-20 US claimed
US-4140532-A ORGANIC SILVER SALT, CATALYST, REDUCING AGENT, 2H-1,3-BENZOTHIAZIN-2,4(3H-)DIONE FUJI PHOTO FILM CO., LTD. (JP) 1979-02-20 US disclosed