Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 6/20 | 0.32 |
| ▸ | SLC6A11 | P48066 | 6/20 | 0.32 |
| ▸ | SLC6A13 | Q9NSD5 | 6/20 | 0.32 |
| ▸ | SLC6A1 | P30531 | 3/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.32 |
| ▸ | ABAT | P80404 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11544412 | 1.00 | SLC6A12 (0.32) | SLC6A12SLC6A11SLC6A13SLC6A1GABRA5 | |
| SCHEMBL11106599 | 1.00 | SLC6A12 (0.32) | SLC6A12SLC6A11SLC6A13SLC6A1GABRA5 | |
| SCHEMBL6256551 | 1.00 | SLC6A12 (0.32) | SLC6A12SLC6A11SLC6A13SLC6A1GABRA5 | |
| SCHEMBL11106595 | 1.00 | SLC6A12 (0.32) | SLC6A12SLC6A11SLC6A13SLC6A1GABRA5 | |
| SCHEMBL31338983 | 0.86 | — | — | |
| SCHEMBL11852671 | 0.79 | SLC6A12 (0.34) | SLC6A12SLC6A11SLC6A13SLC6A1GABRA5 | |
| SCHEMBL11546626 | 0.79 | BLM (0.30) | — | |
| SCHEMBL16599682 | 0.77 | SLC6A12 (0.31) | SLC6A12SLC6A11SLC6A13ABAT | |
| SCHEMBL9457831 | 0.76 | GAA (0.36) | — | |
| SCHEMBL11547816 | 0.76 | TSHR (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4140708-A | Asymmetric synthesis of optically active prostaglandins | HOFFMANN-LA ROCHE INC. (US) | 1979-02-20 | — | — | US | disclosed |
| US-4137244-A | Asymmetric synthesis of optically active prostaglandins | HOFFMANN-LA ROCHE INC. (US) | 1979-01-30 | — | — | US | disclosed |
| US-4133818-A | Process for producing lactones | HOFFMANN-LA ROCHE INC. (US) | 1979-01-09 | — | — | US | disclosed |
| US-4127736-A | 2-Hydroxyethyl-3-cyclopenten-1-ols and derivatives thereof | HOFFMANN-LA ROCHE INC. (US) | 1978-11-28 | — | — | US | disclosed |
| US-4115452-A | 4,5, Substituted cyclopentane-1,3-diols | HOFFMANN-LA ROCHE INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-3933892-A | Asymmetric synthesis of optically active prostaglandins | HOFFMANN-LA ROCHE INC. (US) | 1976-01-20 | — | — | US | disclosed |