SLC6A12 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1249676	0.57	5/20
SCHEMBL1249678	0.57	5/20
SCHEMBL1249680	0.57	5/20
SCHEMBL1251294	0.57	5/20
SCHEMBL1251296	0.57	5/20
SCHEMBL431287	0.54	5/20
SCHEMBL200896	0.50	5/20
SCHEMBL200897	0.50	5/20
SCHEMBL229034	0.50	5/20
SCHEMBL336991	0.43	5/20
SCHEMBL1067170	0.40	5/20
SCHEMBL1367494	0.62	4/20
SCHEMBL43486	0.51	4/20
SCHEMBL44023	0.69	3/20
SCHEMBL1401433	0.61	3/20
SCHEMBL1401434	0.61	3/20
SCHEMBL1401472	0.59	3/20
SCHEMBL1366388	0.59	3/20
SCHEMBL377179	0.54	3/20
SCHEMBL62381	0.51	3/20

Clinical trials — most relevant to SLC6A12 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effect of N-acetylcysteine on Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial.	PHASE4	UNKNOWN
Febuxostat, Blood Pressure and the Intrarenal Renin-Angiotensin System (RAS)	PHASE4	COMPLETED
Nebivolol Effect on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients	PHASE4	COMPLETED
Dapagliflozin Effect on Erythropoiesis and Physical Fitness	PHASE4	WITHDRAWN
Betaine Effect in Speed-strength Athletes	PHASE2/PHASE3	UNKNOWN
D-amino Acid Oxidase Inhibition (DAAOI-1) add-on Treatment for Chronic Schizophrenia	PHASE2	COMPLETED
Therapeutic Effect of Recombinant Human Growth Hormone (rhGH) on the Myopathy of Cystinosis	PHASE1/PHASE2	WITHDRAWN
Investigating the Efficacy of Ergothioneine to Delay Cognitive Decline (Pilot)	PHASE1/PHASE2	COMPLETED
DAAOI-1 Treatment for Treatment-resistant Schizophrenia	PHASE2	COMPLETED
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia	PHASE1/PHASE2	RECRUITING
N-acetylcysteine (NAC) for Improving Cognitive Dysfunction in Schizophrenia	PHASE1	COMPLETED
Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure	EARLY_PHASE1	COMPLETED
Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure	EARLY_PHASE1	COMPLETED
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters	EARLY_PHASE1	COMPLETED
Lithium Countertransport and Blood Pressure In CARDIA and TOMHS	nan	COMPLETED
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle	nan	COMPLETED
POTASSIUM-RICH SALT SUBSTITUTES IN KIDNEY TRANSPLANT RECIPIENTS	nan	NOT_YET_RECRUITING
Oxalate and Citrate in Humans - Response to Citrate	nan	RECRUITING
I-123 Brain Studies of Serotonin Metabolism in Psychiatric Patients and Normal Volunteers	nan	COMPLETED
The Effect of a Diet Based on Low Sodium and Slowly Absorbed Carbohydrates on the Incidence of Refeeding Syndrome in Patients With Head and Neck Cancer	nan	COMPLETED
Bronchial Trans-epithelial Transport in Patients With Idiopathic Multiple Dilations of the Bronchi	nan	COMPLETED
Gubbio Study Five-year Follow-up: Lithium Countertransport, Blood Pressure, and Other Variables	nan	COMPLETED
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
Mapping Brain Glutamate in Humans: Sex Differences in Cigarette Smokers	nan	COMPLETED
Evaluation of Renal Function in Patients With Hyperthyroidism	nan	NOT_YET_RECRUITING
Hydroxyl Free Radical Associated Effects of SGLT-2 Inhibitors in Type 2 Diabetes	nan	COMPLETED
Expression of SLC25A48 in Chronic Obstructive Pulmonary Disease	nan	NOT_YET_RECRUITING
Oxalate and Citrate	nan	RECRUITING
Impact of Dietary Sodium Supplementation on Growth & Intestinal Microbiome	nan	COMPLETED
CRF vs WCRF or PRF-DRG in CLBP of FJ Origin and RFA Failure of MBDR: Central Sensitization and Aberrant Nerve Sprouting	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a SLC6A12 binder may also engage these)

Protein	Name	Similarity
P31646	—	1.000	P31646 →
P48056	—	1.000	P48056 →
P31651	—	1.000	P31651 →
P31649	—	1.000	P31649 →
P27799	—	1.000	P27799 →
SLC6A13	Sodium- and chloride-dependent GABA transporter 2	1.000	landscape →
P48055	—	1.000	P48055 →
SLC6A6	Sodium- and chloride-dependent taurine transporter	1.000	landscape →
Q9MZ34	—	1.000	Q9MZ34 →
O88575	—	1.000	O88575 →
P28572	—	0.999	P28572 →
P31652	—	0.999	P31652 →
Q9MYX0	—	0.999	Q9MYX0 →
A5PJX7	—	0.999	A5PJX7 →
Q28039	—	0.999	Q28039 →
O18875	—	0.999	O18875 →
SLC6A11	Sodium- and chloride-dependent GABA transporter 3	0.999	landscape →
O35316	—	0.999	O35316 →
SLC6A4	Sodium-dependent serotonin transporter	0.999	landscape →
Q61327	—	0.999	Q61327 →
P23977	—	0.998	P23977 →
Q00589	—	0.998	Q00589 →
P31647	—	0.998	P31647 →
Q9NP91	—	0.997	Q9NP91 →
P48029	—	0.997	P48029 →
Q9GJT6	—	0.997	Q9GJT6 →
Q9UN76	—	0.997	Q9UN76 →
P31661	—	0.997	P31661 →
P48057	—	0.997	P48057 →
Q2PG55	—	0.997	Q2PG55 →