SCHEMBL11544669

SCHEMBL11544669

COc1ccc2c(=O)[nH]c(=O)sc2c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 1/20 0.68
PDE3A Q14432 1/20 0.68
PARP15 Q460N3 1/20 0.50
PARP14 Q460N5 1/20 0.50
PARP10 Q53GL7 1/20 0.50
TNKS2 Q9H2K2 1/20 0.50
PARP2 Q9UGN5 1/20 0.50
KDM4E B2RXH2 6/20 0.47
ALDH1A1 P00352 5/20 0.47
HTT P42858 3/20 0.47
NPSR1 Q6W5P4 3/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
HPGD P15428 2/20 0.47
HCRTR1 O43613 1/20 0.47
PPARG P37231 2/20 0.47
NCOA2 Q15596 2/20 0.47
RXFP1 Q9HBX9 2/20 0.47
TSHR P16473 2/20 0.47
PRNP P04156 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11544077 0.81 KDM4E (0.50) PDE3BPDE3APARP15PARP10TNKS2
SCHEMBL1848088 0.81 PDE3B (1.00) PDE3BPDE3AKDM4EALDH1A1HTT
SCHEMBL11537398 0.81 MAOA (0.44) PDE3BPDE3APARP14HTTKMT2A
SCHEMBL30017661 0.77 KDM4E (0.67) PDE3BPDE3AKDM4EALDH1A1HTT
SCHEMBL13338880 0.77 KDM4E (0.67) PDE3BPDE3AKDM4EALDH1A1HTT
SCHEMBL9404662 0.76 PARP15 (0.50) PDE3BPDE3APARP15PARP14PARP10
SCHEMBL8799197 0.76 PDE3B (0.77) PDE3BPDE3AKDM4EALDH1A1HTT
SCHEMBL6228576 0.76 MAOA (0.59) PDE3BPDE3APARP15PARP14PARP10
SCHEMBL11542431 0.75 PDE3B (0.49) PDE3BPDE3APARP15PARP14PARP10
SCHEMBL26785799 0.74 PARP15 (0.58) PARP15PARP14PARP10TNKS2PARP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4140532-A ORGANIC SILVER SALT, CATALYST, REDUCING AGENT, 2H-1,3-BENZOTHIAZIN-2,4(3H-)DIONE FUJI PHOTO FILM CO., LTD. (JP) 1979-02-20 US disclosed