Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.67 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.67 |
| ▸ | DRD4 | P21917 | 4/20 | 0.67 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.57 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9268670 | 0.87 | DRD4 (0.69) | DRD4KMT2AKDM4ELMNAMITF | |
| SCHEMBL12651142 | 0.85 | HDAC1 (0.57) | OPRM1OPRD1OPRK1DRD4PARP10 | |
| SCHEMBL1123563 | 0.84 | MAPT (0.68) | DRD4KMT2AKDM4ELMNAMITF | |
| SCHEMBL8976099 | 0.84 | DRD4 (0.65) | DRD4KMT2AKDM4ELMNAMITF | |
| SCHEMBL12651246 | 0.81 | MAOB (0.62) | OPRM1OPRD1OPRK1DRD4PARP10 | |
| SCHEMBL7414882 | 0.81 | OPRM1 (0.68) | OPRM1OPRD1OPRK1DRD4KMT2A | |
| SCHEMBL8740486 | 0.81 | DRD4 (1.00) | DRD4KMT2AGAAPPARGDRD2 | |
| SCHEMBL3690849 | 0.81 | OPRM1 (0.82) | OPRM1OPRD1OPRK1PARP10KMT2A | |
| SCHEMBL3692341 | 0.81 | OPRM1 (1.00) | OPRM1OPRD1OPRK1PARP10KMT2A | |
| SCHEMBL580098 | 0.81 | OPRM1 (1.00) | OPRM1OPRD1OPRK1PARP10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4147869-A | ADRENERGIC BLOCKING AGENTS FOR TREATMENT OF ANGINA PECTORIS, ARRHYTHMIA AND HYPERTENSION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1979-04-03 | — | — | US | disclosed |
| US-4137328-A | CONGESTIVE HEART FAILURE | PFIZER INC. (US) | 1979-01-30 | — | — | US | disclosed |