Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Imidazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imidazole SCHEMBL9207131 | 1.00 | — | — | |
| Imidazole SCHEMBL1750046 | 0.97 | — | — | |
| Imidazole SCHEMBL28708578 | 0.95 | — | — | |
| Imidazole SCHEMBL28174404 | 0.95 | ALDH1A1 (0.65) | ALDH1A1FKBP5TSHR | |
| Imidazole SCHEMBL28128473 | 0.90 | ALDH1A1 (0.72) | ALDH1A1FKBP5 | |
| Imidazole SCHEMBL28524930 | 0.89 | ALDH1A1 (0.56) | ALDH1A1FKBP5 | |
| Imidazole SCHEMBL28511019 | 0.88 | — | — | |
| Imidazole SCHEMBL1819017 | 0.87 | — | — | |
| Imidazole SCHEMBL28447389 | 0.87 | ALDH1A1 (0.77) | ALDH1A1FKBP5 | |
| Butyl Alcohol SCHEMBL2873502 | 0.85 | ALDH1A1 (0.52) | ALDH1A1FKBP5TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4146630-A | HYPOTENSIVE AGENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1979-03-27 | — | — | US | disclosed |