Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 3/20 | 0.43 |
| ▸ | MVD | P53602 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PEPD | P12955 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11546798 | 0.87 | ACE (0.48) | ACERAB9AALDH1A1RENMVD | |
| SCHEMBL11546031 | 0.84 | ACE (0.44) | ACERAB9AALDH1A1RENMVD | |
| SCHEMBL11413122 | 0.82 | ACE (0.56) | ACERENLMNAHSD17B10CYP2C19 | |
| SCHEMBL7376055 | 0.82 | ACE (0.56) | ACERENLMNAHSD17B10CYP2C19 | |
| SCHEMBL11618236 | 0.81 | ACE (0.55) | ACERAB9AALDH1A1RENMVD | |
| SCHEMBL11549350 | 0.79 | ACE (0.50) | ACERENLMNAHSD17B10CYP2C19 | |
| SCHEMBL11547990 | 0.79 | ALDH1A1 (0.42) | ACERAB9AALDH1A1MVDKDM4E | |
| SCHEMBL11549942 | 0.79 | ACE (0.50) | ACERAB9ARENLMNAHSD17B10 | |
| SCHEMBL9392065 | 0.79 | ALDH1A1 (0.60) | ACERAB9AALDH1A1RENLMNA | |
| SCHEMBL5495836 | 0.78 | ACE (0.52) | ACERAB9AALDH1A1RENMVD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |