Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27652136 | 0.87 | CYP2D6 (0.44) | CYP2D6CYP1A2CYP2C19HIF1AKMT2A | |
| SCHEMBL6950057 | 0.85 | CYP2D6 (0.57) | CYP2D6CYP1A2CYP2C19HIF1AMAPT | |
| SCHEMBL27632932 | 0.82 | MAPT (0.53) | CYP2D6CYP1A2CYP2C19HIF1AMAPT | |
| SCHEMBL3521078 | 0.80 | CES1 (0.50) | CYP2D6CYP1A2CYP2C19HIF1AMAPT | |
| SCHEMBL10717791 | 0.79 | KCNN4 (0.58) | CYP2D6CYP1A2CYP2C19HIF1AMAPT | |
| SCHEMBL9098516 | 0.77 | CYP2D6 (0.52) | CYP2D6CYP1A2CYP2C19HIF1AMAPT | |
| SCHEMBL28905915 | 0.75 | CYP2C9 (0.58) | CYP2D6CYP1A2CYP2C19HIF1AMAPT | |
| SCHEMBL3396019 | 0.73 | CYP2D6 (0.53) | CYP2D6CYP1A2CYP2C19HIF1AMAPT | |
| SCHEMBL11826485 | 0.73 | CYP2D6 (0.48) | CYP2D6CYP1A2CYP2C19HIF1AMAPT | |
| SCHEMBL11831124 | 0.73 | CYP2D6 (0.48) | CYP2D6CYP1A2CYP2C19HIF1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4169202-A | Process for preparing 4,5-dihydro-4-oxofuran-2-carboxylic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1979-09-25 | — | — | US | disclosed |