Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.56 |
| ▸ | REN | P00797 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | MVD | P53602 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6788316 | 0.94 | ACE (0.62) | ACERENCHRM2CHRM4CHRM1 | |
| SCHEMBL6788307 | 0.94 | ACE (0.62) | ACERENCHRM2CHRM4CHRM1 | |
| SCHEMBL11546483 | 0.87 | ACE (0.55) | ACERENCHRM2CHRM4CHRM1 | |
| SCHEMBL6782701 | 0.82 | ACE (0.72) | ACERENMVD | |
| SCHEMBL6782705 | 0.82 | ACE (0.72) | ACERENMVD | |
| SCHEMBL9392065 | 0.81 | ALDH1A1 (0.60) | ACEREN | |
| SCHEMBL11548796 | 0.81 | ACE (0.49) | ACERENCHRM2CHRM4CHRM1 | |
| SCHEMBL11550932 | 0.81 | ACE (0.58) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL26644319 | 0.81 | ACE (0.62) | ACERENCHRM2CHRM4CHRM1 | |
| SCHEMBL11559272 | 0.80 | ACE (0.66) | ACERENCHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |