SCHEMBL11546161

SCHEMBL11546161

CCOC(=O)/C(=C\c1ccc(Br)cc1)C(C)=O

nearest known ligand 0.85

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 9/20 0.85
MAPT P10636 9/20 0.85
MEN1 O00255 8/20 0.85
LMNA P02545 4/20 0.85
NPSR1 Q6W5P4 3/20 0.85
S1PR4 O95977 1/20 0.85
S1PR1 P21453 1/20 0.85
MAPK1 P28482 1/20 0.85
CYP1A2 P05177 2/20 0.60
CYP2C9 P11712 2/20 0.60
CYP2C19 P33261 2/20 0.60
KDM4E B2RXH2 6/20 0.60
ALDH1A1 P00352 6/20 0.60
HSP90AA1 P07900 3/20 0.60
HPGD P15428 1/20 0.60
GLO1 Q04760 2/20 0.53
PTGS2 P35354 1/20 0.53
SMN1; SMN2 Q16637 4/20 0.50
NR1H4 Q96RI1 1/20 0.50
CRHBP P24387 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11546170 1.00 KMT2A (0.85) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL1673521 0.92 KMT2A (1.00) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL9122107 0.88 KMT2A (0.66) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL9122099 0.88 KMT2A (0.66) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL2812585 0.88 MAPT (0.85) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL10890387 0.87 KMT2A (0.65) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL10890390 0.87 KMT2A (0.65) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL11547023 0.87 KMT2A (0.65) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL7700121 0.86 KDM4E (0.66) KMT2AMAPTMEN1LMNANPSR1
SCHEMBL7700123 0.86 KDM4E (0.66) KMT2AMAPTMEN1LMNANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4136187-A CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DE) 1979-01-23 US disclosed
US-4053614-A 1,2-PENTAMETHYLENE-1,4-DIHYDROPYRIDINE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DT) 1977-10-11 US disclosed
US-4024261-A HYPERTENSIVE AGENTS, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1977-05-17 US disclosed
US-4022898-A ANTIHYPERTENSIVE AGENTS, VASODILATORS BAYER AKTIENGESELLSCHAFT (DT) 1977-05-10 US disclosed
US-4004015-A Bicyclic derivatives of 1,4-dihydropyridine as antihypertensive agents and coronary vessel dilators BAYER AKTIENGESELLSCHAFT (DT) 1977-01-18 US disclosed
US-4001235-A HYPOTENSIVES, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1977-01-04 US disclosed
US-4001258-A HYPOTENSIVES, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1977-01-04 US disclosed
US-3971790-A VASODILATION, HYPOTENSIVE BAYER AKTIENGESELLSCHAFT (DT) 1976-07-27 US disclosed
US-3971791-A VASODILATION, HYPOTENSIVE BAYER AKTIENGESELLSCHAFT (DT) 1976-07-27 US disclosed
US-3959292-A HYPOTENSIVE AGENTS, CORONARY DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1976-05-25 US disclosed
US-3951994-A HYPOTENSIVE, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1976-04-20 US disclosed
US-3951988-A HYPOTENSIVE, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1976-04-20 US disclosed
US-3948923-A HYPOTENSIVE, VASODILATION BAYER AKTIENGESELLSCHAFT (DT) 1976-04-06 US disclosed
US-3946026-A HYPOTENSIVE AGENTS, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1976-03-23 US disclosed
US-3939171-A HYPOTENSIVE, VASODILATION BAYER AKTIENGESELLSCHAFT (DT) 1976-02-17 US disclosed
US-3935220-A VASODILATION, HYPOTENSIVE BAYER AKTIENGESELLSCHAFT (DT) 1976-01-27 US disclosed
US-3935223-A 2-Amino-1,4-dihydropyridine derivatives BAYER AKTIENGESELLSCHAFT (DT) 1976-01-27 US disclosed