Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terfenadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.98 |
| ▸ | LMNA | P02545 | 3/20 | 0.98 |
| ▸ | DRD3 | P35462 | 3/20 | 0.98 |
| ▸ | DRD2 | P14416 | 2/20 | 0.98 |
| ▸ | HTR2A | P28223 | 2/20 | 0.98 |
| ▸ | HTR2B | P41595 | 2/20 | 0.98 |
| ▸ | BLM | P54132 | 2/20 | 0.98 |
| ▸ | CYP2J2 | P51589 | 2/20 | 0.98 |
| ▸ | MEN1 | O00255 | 1/20 | 0.98 |
| ▸ | NPC1 | O15118 | 1/20 | 0.98 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.98 |
| ▸ | GMNN | O75496 | 1/20 | 0.98 |
| ▸ | USP2 | O75604 | 1/20 | 0.98 |
| ▸ | EGFR | P00533 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | FYN | P06241 | 1/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terfenadine SCHEMBL5152 | 0.99 | KCNH2 (1.00) | KCNH2LMNAHRH1DRD3DRD2 | |
| R-Terfenadine SCHEMBL155924 | 0.99 | KCNH2 (1.00) | KCNH2LMNAHRH1DRD3DRD2 | |
| Terfenadine SCHEMBL5999024 | 0.99 | KCNH2 (1.00) | KCNH2LMNAHRH1DRD3DRD2 | |
| SCHEMBL11857869 | 0.99 | KCNH2 (1.00) | KCNH2LMNAHRH1DRD3DRD2 | |
| Terfenadine SCHEMBL5998456 | 0.99 | KCNH2 (1.00) | KCNH2LMNAHRH1DRD3DRD2 | |
| Terfenadine SCHEMBL5999023 | 0.99 | KCNH2 (1.00) | KCNH2LMNAHRH1DRD3DRD2 | |
| R-Terfenadine SCHEMBL17732284 | 0.98 | KCNH2 (0.98) | KCNH2LMNAHRH1DRD3DRD2 | |
| Terfenadine SCHEMBL17732283 | 0.98 | KCNH2 (0.98) | KCNH2LMNAHRH1DRD3DRD2 | |
| Terfenadine SCHEMBL27965234 | 0.98 | KCNH2 (0.98) | KCNH2LMNAHRH1DRD3DRD2 | |
| SCHEMBL11871354 | 0.97 | KCNH2 (0.96) | KCNH2LMNAHRH1DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118019758-A | Nucleic acids encoding reduced immunogenicity factor VIII polypeptides | 比奥维拉迪维治疗股份有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-116033927-A | Method for removing free factor VIII from a preparation of lentiviral vectors modified to express factor VIII | 比奥维拉迪维治疗股份有限公司 | 2023-04-28 | — | — | CN | disclosed |
| CN-115279896-A | Lentiviral vector formulations | 比奥维拉迪维治疗股份有限公司 | 2022-11-01 | — | — | CN | disclosed |
| CN-113396223-A | Use of lentiviral vectors expressing factor IX | 比奥维拉迪维治疗股份有限公司 | 2021-09-14 | — | — | CN | disclosed |
| CN-111918674-A | Use of lentiviral vectors expressing factor VIII | 比奥维拉迪维治疗股份有限公司 | 2020-11-10 | — | — | CN | disclosed |
| US-4180583-A | ANTIHISTAMINES, ANTIALLERGENS AND BRONCHODILATOR AGENTS | RICHARDSON-MERRELL INC. (US) | 1979-12-25 | — | — | US | disclosed |