Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terfenadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.98 |
| ▸ | LMNA | P02545 | 3/20 | 0.98 |
| ▸ | DRD3 | P35462 | 3/20 | 0.98 |
| ▸ | HTR2A | P28223 | 2/20 | 0.98 |
| ▸ | HTR2B | P41595 | 2/20 | 0.98 |
| ▸ | BLM | P54132 | 2/20 | 0.98 |
| ▸ | DRD2 | P14416 | 2/20 | 0.98 |
| ▸ | CYP2J2 | P51589 | 2/20 | 0.98 |
| ▸ | MEN1 | O00255 | 1/20 | 0.98 |
| ▸ | NPC1 | O15118 | 1/20 | 0.98 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.98 |
| ▸ | GMNN | O75496 | 1/20 | 0.98 |
| ▸ | USP2 | O75604 | 1/20 | 0.98 |
| ▸ | EGFR | P00533 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | FYN | P06241 | 1/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| R-Terfenadine SCHEMBL17732284 | 1.00 | KCNH2 (0.98) | KCNH2LMNAHRH1DRD3HTR2A | |
| SCHEMBL11857869 | 0.99 | KCNH2 (1.00) | KCNH2LMNAHRH1DRD3HTR2A | |
| Terfenadine SCHEMBL5152 | 0.99 | KCNH2 (1.00) | KCNH2LMNAHRH1DRD3HTR2A | |
| R-Terfenadine SCHEMBL155924 | 0.99 | KCNH2 (1.00) | KCNH2LMNAHRH1DRD3HTR2A | |
| Terfenadine SCHEMBL5998456 | 0.99 | KCNH2 (1.00) | KCNH2LMNAHRH1DRD3HTR2A | |
| Terfenadine SCHEMBL5999023 | 0.99 | KCNH2 (1.00) | KCNH2LMNAHRH1DRD3HTR2A | |
| Terfenadine SCHEMBL5999024 | 0.99 | KCNH2 (1.00) | KCNH2LMNAHRH1DRD3HTR2A | |
| Terfenadine SCHEMBL11546558 | 0.98 | KCNH2 (0.98) | KCNH2LMNAHRH1DRD3HTR2A | |
| Terfenadine SCHEMBL27965234 | 0.98 | KCNH2 (0.98) | KCNH2LMNAHRH1DRD3HTR2A | |
| SCHEMBL11871354 | 0.97 | KCNH2 (0.96) | KCNH2LMNAHRH1DRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016073179-A2 | NOVEL CHRONOTHERAPY BASED ON CIRCADIAN RHYTHMS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-05-12 | — | — | WO | disclosed |