Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.41 |
| ▸ | EPOR | P19235 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11546806 | 0.88 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2PPARDNPC1 | |
| SCHEMBL11546998 | 0.87 | ALDH1A1 (0.58) | KDM4EALDH1A1SMN1; SMN2PKMRAB9A | |
| SCHEMBL11545984 | 0.87 | KDM4E (0.52) | KDM4EALDH1A1SMN1; SMN2PKMNPC1 | |
| SCHEMBL11543497 | 0.82 | NR4A2 (0.59) | KDM4ESMN1; SMN2PPARDNPC1RAB9A | |
| SCHEMBL11544902 | 0.82 | MAPT (0.55) | KDM4EALDH1A1SMN1; SMN2PKMCYP26B1 | |
| SCHEMBL11574926 | 0.79 | PPARD (0.46) | KDM4ESMN1; SMN2PPARDNPC1RAB9A | |
| SCHEMBL11551464 | 0.76 | MAPT (0.55) | KDM4EALDH1A1SMN1; SMN2PKMCYP26B1 | |
| SCHEMBL11543976 | 0.76 | CYP1A2 (0.51) | KDM4EALDH1A1SMN1; SMN2CYP26B1TRPV1 | |
| SCHEMBL11683611 | 0.75 | KDM4E (0.70) | KDM4EALDH1A1SMN1; SMN2PKMEPOR | |
| SCHEMBL11683613 | 0.75 | KDM4E (0.70) | KDM4EALDH1A1SMN1; SMN2PKMEPOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4144351-A | ANTICHOLESTEROL | KLINGE PHARMA GMBH & CO. (DE) | 1979-03-13 | — | — | US | disclosed |
| US-4109013-A | SUBSTITUTED PROPANOL-(2) DERIVATIVES OF HYDROXAMIC ACIDS AND THE USE THEREOF AS HYPOLIPEMIC DRUGS | KLINGE PHARMA GMBH & CO. (DE) | 1978-08-22 | — | — | US | disclosed |
| US-4073935-A | Substituted propanol-(2)-derivatives and their nicotinic acid esters, and process for their preparation, and the use thereof as hypolipemic drugs | KLINGE PHARMA GMBH & CO. (DT) | 1978-02-14 | — | — | US | disclosed |