Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11543459 | 0.99 | KDM4E (0.64) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| SCHEMBL11546298 | 0.90 | KDM4E (0.57) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| SCHEMBL11543553 | 0.83 | ALDH1A1 (0.49) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| SCHEMBL11547078 | 0.81 | KDM4E (0.64) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| SCHEMBL11545473 | 0.80 | KDM4E (0.63) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| SCHEMBL11548776 | 0.80 | KDM4E (0.62) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| Piretanide SCHEMBL49473 | 0.79 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| SCHEMBL10281400 | 0.79 | KDM4E (0.61) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| Piretanide SCHEMBL30230376 | 0.79 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDUSP2 | |
| Piretanide SCHEMBL1741994 | 0.79 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4161531-A | Diuretic and saluretic 5-sulfamoylbenzoic acid derivatives carrying a heterocyclic substituent | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-17 | — | — | US | disclosed |
| US-4118397-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
| US-4111953-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4093735-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-06 | — | — | US | disclosed |
| US-4010273-A | DIURETICS, SALURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-03-01 | — | — | US | disclosed |