Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | LIG1 | P18858 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10642594 | 0.71 | CHRNB2 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4LIG1 | |
| SCHEMBL4916750 | 0.69 | NPC1 (0.33) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL4286992 | 0.69 | MAPT (0.33) | CHRNB2CHRNB4CHRNA3CHRNA4LIG1 | |
| SCHEMBL445846 | 0.67 | — | — | |
| SCHEMBL3649976 | 0.67 | — | — | |
| SCHEMBL8177565 | 0.63 | MAPT (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4LIG1 | |
| SCHEMBL21436602 | 0.63 | — | — | |
| SCHEMBL557766 | 0.63 | — | — | |
| SCHEMBL8639905 | 0.62 | SMN1; SMN2 (0.39) | CHRNB2CHRNB4CHRNA3CHRNA4CA12 | |
| SCHEMBL8567670 | 0.62 | KDM4E (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4139623-A | HYPOTENSIVE AGENTS | C-G CORP. (US) | 1979-02-13 | — | — | US | disclosed |
| US-4027027-A | BETA-RECEPTOR-BLOCKERS, HYPOTENSIVES AND VALODILATORS; FOR TREATING ARRYTHMIAS AND ANGINA PECTORIS | CIBA-GEIGY CORPORATION (US) | 1977-05-31 | — | — | US | disclosed |