Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11547970 | 1.00 | CYP1A2 (0.64) | CYP1A2CYP2C9CYP3A4MAPTALDH1A1 | |
| SCHEMBL11547104 | 0.82 | ALDH1A1 (0.71) | CYP1A2CYP2C9CYP3A4MAPTALDH1A1 | |
| SCHEMBL11547103 | 0.82 | ALDH1A1 (0.71) | CYP1A2CYP2C9CYP3A4MAPTALDH1A1 | |
| SCHEMBL11550396 | 0.82 | MAPT (0.57) | CYP1A2CYP2C9CYP3A4MAPTALDH1A1 | |
| SCHEMBL11550395 | 0.82 | MAPT (0.57) | CYP1A2CYP2C9CYP3A4MAPTALDH1A1 | |
| SCHEMBL11551487 | 0.81 | MAPT (0.63) | MAPTALDH1A1KDM4EPOLBHTT | |
| SCHEMBL11551482 | 0.81 | MAPT (0.63) | MAPTALDH1A1KDM4EPOLBHTT | |
| SCHEMBL11549124 | 0.81 | MAPT (0.53) | CYP1A2CYP2C9CYP3A4MAPTALDH1A1 | |
| SCHEMBL11549126 | 0.81 | MAPT (0.53) | CYP1A2CYP2C9CYP3A4MAPTALDH1A1 | |
| SCHEMBL4098988 | 0.78 | ALDH1A1 (0.62) | CYP1A2CYP2C9MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4134981-A | ANTIALLERGENS | PFIZER INC. (US) | 1979-01-16 | — | — | US | disclosed |
| US-4120962-A | Fused pyrimidin-4(3H)-ones as antiallergy agents | PFIZER INC. (US) | 1978-10-17 | — | — | US | disclosed |
| US-4044134-A | FUSED WITH QUINOLINE OR PYRIDINE, 2-METHYL, ETHYL, OR ACETYL GROUP | PFIZER INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-3974161-A | Fused pyrimidin-4(3H)-ones as antiallergy agents | PFIZER INC. (US) | 1976-08-10 | — | — | US | disclosed |