Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11551308 | 0.83 | — | — | |
| SCHEMBL15374640 | 0.80 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HTTTSHRL3MBTL1 | |
| SCHEMBL12981839 | 0.77 | — | — | |
| SCHEMBL4609242 | 0.76 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HTTTSHRL3MBTL1 | |
| SCHEMBL2735121 | 0.76 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HTTTSHRL3MBTL1 | |
| SCHEMBL23176125 | 0.75 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HTTTSHRL3MBTL1 | |
| SCHEMBL172715 | 0.75 | ALDH1A1 (0.46) | ALDH1A1TSHRLMNAKMT2AHSD17B10 | |
| SCHEMBL15750804 | 0.75 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2HTTTSHRL3MBTL1 | |
| SCHEMBL5159311 | 0.74 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2HTTTSHRL3MBTL1 | |
| SCHEMBL13864131 | 0.74 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2HTTTSHRL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004335-A2 | Prostacyclin analogs, process and intermediates for their preparation and their use as medicines | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-10-03 | — | — | EP | disclosed |
| EP-0001270-A1 | Analogues of prostacycline, methods for their preparation and their use in the treatment of circulatory diseases | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-04-04 | — | — | EP | disclosed |