Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11548603 | 1.00 | MAPT (0.39) | MAPTSMN1; SMN2LMNATP53TSHR | |
| SCHEMBL16599630 | 0.83 | MAPT (0.40) | MAPTSMN1; SMN2LMNATP53TSHR | |
| SCHEMBL15974381 | 0.83 | MAPT (0.40) | MAPTSMN1; SMN2LMNATP53TSHR | |
| SCHEMBL10836267 | 0.81 | MAPT (0.39) | MAPTSMN1; SMN2LMNATP53TSHR | |
| SCHEMBL16614399 | 0.79 | MAPT (0.37) | MAPTSMN1; SMN2LMNATP53TSHR | |
| SCHEMBL11544417 | 0.76 | — | — | |
| SCHEMBL11546128 | 0.76 | — | — | |
| SCHEMBL11551214 | 0.75 | — | — | |
| SCHEMBL11544521 | 0.75 | — | — | |
| SCHEMBL11546894 | 0.74 | MAPT (0.34) | MAPTCA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4140708-A | Asymmetric synthesis of optically active prostaglandins | HOFFMANN-LA ROCHE INC. (US) | 1979-02-20 | — | — | US | claimed |
| US-4140708-A | Asymmetric synthesis of optically active prostaglandins | HOFFMANN-LA ROCHE INC. (US) | 1979-02-20 | — | — | US | disclosed |
| US-4137244-A | Asymmetric synthesis of optically active prostaglandins | HOFFMANN-LA ROCHE INC. (US) | 1979-01-30 | — | — | US | disclosed |
| US-4133818-A | Process for producing lactones | HOFFMANN-LA ROCHE INC. (US) | 1979-01-09 | — | — | US | disclosed |
| US-4127736-A | 2-Hydroxyethyl-3-cyclopenten-1-ols and derivatives thereof | HOFFMANN-LA ROCHE INC. (US) | 1978-11-28 | — | — | US | disclosed |
| US-4115452-A | 4,5, Substituted cyclopentane-1,3-diols | HOFFMANN-LA ROCHE INC. (US) | 1978-09-19 | — | — | US | disclosed |
| US-3933892-A | Asymmetric synthesis of optically active prostaglandins | HOFFMANN-LA ROCHE INC. (US) | 1976-01-20 | — | — | US | disclosed |