Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15974381 | 0.91 | MAPT (0.40) | MAPTTHRBALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL16599630 | 0.91 | MAPT (0.40) | MAPTTHRBALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL3401832 | 0.83 | MAPT (0.30) | MAPTTDP1 | |
| SCHEMBL10076680 | 0.81 | THRB (0.39) | MAPTTHRBALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL15973796 | 0.81 | THRB (0.39) | MAPTTHRBALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL21531500 | 0.81 | THRB (0.39) | MAPTTHRBALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL11548252 | 0.79 | MAPT (0.39) | MAPTTHRBALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL11548603 | 0.79 | MAPT (0.39) | MAPTTHRBALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL10836267 | 0.79 | MAPT (0.39) | MAPTTHRBALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL5859549 | 0.74 | ALDH1A1 (0.44) | MAPTALDH1A1NPSR1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015048268-A1 | SYNTHESIS OF DELTA 12-PGJ3 AND RELATED COMPOUNDS | WILLIAM MARSH RICE UNIVERSITY (US) | 2015-04-02 | — | — | WO | disclosed |