Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11548051 | 0.89 | MAPT (0.53) | SMN1; SMN2KDM4EALDH1A1PKMMAPT | |
| SCHEMBL11620901 | 0.87 | MAPT (0.54) | SMN1; SMN2ALDH1A1PKMMAPTHTT | |
| SCHEMBL11546781 | 0.87 | MAPT (0.54) | SMN1; SMN2ALDH1A1PKMMAPTHTT | |
| SCHEMBL11544902 | 0.87 | MAPT (0.55) | SMN1; SMN2KDM4EALDH1A1PKMMAPT | |
| SCHEMBL11547208 | 0.87 | ALDH1A1 (0.59) | SMN1; SMN2KDM4EALDH1A1PKMMAPT | |
| SCHEMBL11544924 | 0.81 | NR4A2 (0.56) | SMN1; SMN2MAPTHTTMEN1KMT2A | |
| SCHEMBL11545984 | 0.81 | KDM4E (0.52) | SMN1; SMN2KDM4EALDH1A1PKMMAPT | |
| SCHEMBL11551464 | 0.76 | MAPT (0.55) | SMN1; SMN2KDM4EALDH1A1PKMMAPT | |
| SCHEMBL11683611 | 0.75 | KDM4E (0.70) | SMN1; SMN2KDM4EALDH1A1PKMHDAC4 | |
| SCHEMBL11683613 | 0.75 | KDM4E (0.70) | SMN1; SMN2KDM4EALDH1A1PKMHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4144351-A | ANTICHOLESTEROL | KLINGE PHARMA GMBH & CO. (DE) | 1979-03-13 | — | — | US | disclosed |
| US-4109013-A | SUBSTITUTED PROPANOL-(2) DERIVATIVES OF HYDROXAMIC ACIDS AND THE USE THEREOF AS HYPOLIPEMIC DRUGS | KLINGE PHARMA GMBH & CO. (DE) | 1978-08-22 | — | — | US | disclosed |
| US-4073935-A | Substituted propanol-(2)-derivatives and their nicotinic acid esters, and process for their preparation, and the use thereof as hypolipemic drugs | KLINGE PHARMA GMBH & CO. (DT) | 1978-02-14 | — | — | US | disclosed |