Butadiene

Butadiene

SCHEMBL11548723

C=C(C(=O)O)C(C=Cc1ccccc1)C(=O)O.C=CC=C

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.47
CYP3A4 P08684 1/20 0.41
PAM P19021 1/20 0.40
GRIK1 P39086 3/20 0.39
HDAC3 O15379 3/20 0.39
HDAC4 P56524 3/20 0.39
HDAC1 Q13547 3/20 0.39
HDAC2 Q92769 3/20 0.39
HDAC8 Q9BY41 3/20 0.39
HDAC6 Q9UBN7 3/20 0.39
LMNA P02545 3/20 0.39
HDAC7 Q8WUI4 2/20 0.39
HDAC10 Q969S8 2/20 0.39
HDAC11 Q96DB2 2/20 0.39
HDAC9 Q9UKV0 2/20 0.39
HDAC5 Q9UQL6 2/20 0.39
ALDH1A1 P00352 2/20 0.39
PLIN1 O60240 2/20 0.39
MAPT P10636 2/20 0.39
RECQL P46063 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9281647 0.95 CYP1A2 (0.51) CYP1A2CYP3A4PAMGRIK1HDAC3
SCHEMBL29833258 0.86 CYP1A2 (0.46) CYP1A2CYP3A4PAMGRIK1HDAC3
SCHEMBL10454933 0.82 CYP3A4 (0.49) CYP1A2CYP3A4PAMHDAC3HDAC4
SCHEMBL29829688 0.82 CYP1A2 (0.45) CYP1A2CYP3A4PAMGRIK1HDAC3
Butadiene SCHEMBL14976845 0.82 CYP1A2 (0.45) CYP1A2CYP3A4HDAC3HDAC4HDAC1
SCHEMBL30553878 0.82 CYP1A2 (0.49) CYP1A2CYP3A4PAMGRIK1HDAC3
Acrylic Acid Ethyl Ester SCHEMBL11309984 0.81 RAB9A (0.41) CYP1A2LMNAALDH1A1MAPTSMN1; SMN2
SCHEMBL2636177 0.80 CYP1A2 (0.62) CYP1A2PAMGRIK1HDAC3HDAC4
Butadiene SCHEMBL675872 0.78 CYP3A4 (0.42) CYP1A2CYP3A4PAMGRIK1HDAC3
SCHEMBL4250754 0.78 CYP1A2 (0.50) CYP1A2CYP3A4PAMHDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4138389-A VULCANIZABLE BLAND OF ADDITION POLYMERS POLYSAR LIMITED (CA) 1979-02-06 US disclosed