Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL440138 | 0.82 | HTR2A (0.54) | HTR2ARETACP3IDO1PDPK1 | |
| SCHEMBL29793145 | 0.82 | HTR2A (0.54) | HTR2ARETACP3IDO1PDPK1 | |
| SCHEMBL11555667 | 0.81 | ACP3 (0.42) | HTR2ARETACP3DRD3DRD2 | |
| SCHEMBL13802872 | 0.74 | HTR2A (0.45) | HTR2ARETDRD3DRD2CHRM1 | |
| SCHEMBL8353824 | 0.74 | HTR2A (0.45) | HTR2ARETDRD3DRD2CHRM1 | |
| SCHEMBL15985224 | 0.73 | HTR2A (0.44) | HTR2ARETDRD3DRD2HTR1A | |
| SCHEMBL13814261 | 0.70 | RET (0.38) | HTR2ARETGID4LMNAIDO1 | |
| SCHEMBL15985276 | 0.70 | HTR2A (0.42) | HTR2ARETACP3DRD3DRD2 | |
| SCHEMBL15219996 | 0.69 | KEAP1 (0.41) | DRD3DRD2GID4LMNAADRA2A | |
| SCHEMBL15985234 | 0.69 | HTR2A (0.46) | HTR2ARETACP3DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4144337-A | 1,4-Substituted piperazinyl derivatives useful as psychostimulants | SANDOZ LTD. (CH) | 1979-03-13 | — | — | US | disclosed |