Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 12/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.36 |
| ▸ | PEPD | P12955 | 1/20 | 0.33 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12733482 | 0.80 | DPP4 (0.35) | DPP4DPP8DPP7POLBCYP3A4 | |
| SCHEMBL12733475 | 0.80 | DPP4 (0.35) | DPP4DPP8DPP7POLBCYP3A4 | |
| SCHEMBL18555719 | 0.78 | DPP4 (0.36) | DPP4DPP8DPP7PEPDXPNPEP1 | |
| SCHEMBL6002000 | 0.77 | ALDH1A1 (0.39) | DPP4DPP7PEPDXPNPEP1ALDH1A1 | |
| SCHEMBL9603282 | 0.77 | ALDH1A1 (0.31) | ALDH1A1L3MBTL1 | |
| SCHEMBL9603286 | 0.77 | ALDH1A1 (0.31) | ALDH1A1L3MBTL1 | |
| SCHEMBL9603285 | 0.77 | ALDH1A1 (0.31) | ALDH1A1L3MBTL1 | |
| SCHEMBL25300115 | 0.75 | DPP4 (0.37) | DPP4DPP8DPP7PEPDXPNPEP1 | |
| SCHEMBL25261195 | 0.75 | DPP4 (0.37) | DPP4DPP8DPP7PEPDXPNPEP1 | |
| SCHEMBL25303946 | 0.75 | DPP4 (0.37) | DPP4DPP8DPP7PEPDXPNPEP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893103-B2 | Dipeptidyl peptidase IV (DPP-IV); industrial scale process of making antidiabetics such as (2S,4S)-1-{2-[(3SR,1RS)-3-(1H-1,2,4-Triazol-1-ylmethyl)cyclopentylamino]acetyl}-4-fluoro-pyrrolidine-2-carbonitrile starting from ethyl glyoxalate and 3-(1H-1,2,4-triazol-1-ylmethyl)cyclopententylamine for example | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2011-02-22 | — | — | US | disclosed |