Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11550350 | 1.00 | ATM (0.55) | ATMTSHRHPGDRAB9AMAPT | |
| SCHEMBL11563279 | 1.00 | ATM (0.55) | ATMTSHRHPGDRAB9AMAPT | |
| SCHEMBL11563575 | 0.81 | ATM (0.63) | ATMTSHRHPGDRAB9AMAPT | |
| SCHEMBL11555877 | 0.81 | NPSR1 (0.50) | TSHRMAPTNPSR1HCAR2ALDH1A1 | |
| SCHEMBL11548834 | 0.81 | NPSR1 (0.50) | TSHRMAPTNPSR1HCAR2ALDH1A1 | |
| SCHEMBL11548836 | 0.81 | NPSR1 (0.50) | TSHRMAPTNPSR1HCAR2ALDH1A1 | |
| SCHEMBL11567146 | 0.80 | CHRM1 (0.52) | MAPTNPSR1ALDH1A1LMNACYP1A2 | |
| SCHEMBL11560554 | 0.80 | SMN1; SMN2 (0.36) | ATMTSHRRAB9AMAPTNPSR1 | |
| SCHEMBL11567144 | 0.80 | CHRM1 (0.52) | MAPTNPSR1ALDH1A1LMNACYP1A2 | |
| SCHEMBL11560557 | 0.80 | SMN1; SMN2 (0.36) | ATMTSHRRAB9AMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4162321-A | Sulphur-containing amino-dihydropyridines, and their use as medicants | BAYER AKTIENGESELLSCHAFT (DE) | 1979-07-24 | — | — | US | disclosed |
| US-4136187-A | CORONARY VESSEL DILATORS | BAYER AKTIENGESELLSCHAFT (DE) | 1979-01-23 | — | — | US | disclosed |
| US-4004014-A | VASODILATION, HYPOTENSIVE, ANTIARRHYTHMIA, SPASMOLYTIC | BAYER AKTIENGESELLSCHAFT (DT) | 1977-01-18 | — | — | US | disclosed |
| US-3959292-A | HYPOTENSIVE AGENTS, CORONARY DILATORS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-25 | — | — | US | disclosed |