Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 5/20 | 0.52 |
| ▸ | NR2E1 | Q9Y466 | 5/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | HTR2B | P41595 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.48 |
| ▸ | SCN1A | P35498 | 2/20 | 0.48 |
| ▸ | SLC10A1 | Q14973 | 2/20 | 0.48 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11556572 | 0.87 | HTR1B (0.58) | HTR1BNR2E1SLC6A4ADRB2ADRB1 | |
| SCHEMBL9329796 | 0.85 | ADRB2 (0.64) | HTR1BNR2E1SLC6A4ADRB2ADRB1 | |
| SCHEMBL11553331 | 0.83 | HTR1B (0.62) | HTR1BNR2E1SLC6A4ALDH1A1HTR1A | |
| SCHEMBL18466199 | 0.76 | ADRB2 (0.67) | HTR1BNR2E1SLC6A4ADRB2ADRB1 | |
| SCHEMBL4845731 | 0.76 | ADRB2 (0.67) | HTR1BNR2E1SLC6A4ADRB2ADRB1 | |
| SCHEMBL14477159 | 0.75 | HTR1B (0.53) | HTR1BNR2E1SLC6A4CYP1A2HRH1 | |
| SCHEMBL11552225 | 0.74 | HTR1B (0.54) | HTR1BNR2E1SLC6A4ADRB2ADRB1 | |
| SCHEMBL18466290 | 0.74 | HTR1B (0.91) | HTR1BNR2E1SLC6A4ALDH1A1HTR1A | |
| SCHEMBL9762578 | 0.73 | HTR1B (0.78) | HTR1BNR2E1SLC6A4ALDH1A1HTR1A | |
| SCHEMBL9244006 | 0.73 | NR2E1 (0.60) | HTR1BNR2E1SLC6A4ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4140779-A | ANTIDEPRESSANTS | AYERST, MCKENNA AND HARRISON LIMITED (CA) | 1979-02-20 | — | — | US | disclosed |