⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1054620 | 0.69 | — | — | |
| SCHEMBL1576131 | 0.68 | — | — | |
| SCHEMBL14534464 | 0.64 | — | — | |
| SCHEMBL831131 | 0.64 | ALDH1A1 (0.32) | — | |
| SCHEMBL22037 | 0.64 | — | — | |
| SCHEMBL9048349 | 0.63 | — | — | |
| SCHEMBL2012202 | 0.62 | — | — | |
| SCHEMBL9050227 | 0.62 | — | — | |
| SCHEMBL5462876 | 0.62 | — | — | |
| SCHEMBL122550 | 0.61 | ALDH1A1 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 577 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | claimed |
| US-8536195-B2 | Bicyclic derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-09-17 | — | — | US | claimed |
| US-20130084639-A1 | Bicyclic Derivatives as Modulators of Ion Channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-04-04 | — | — | US | claimed |
| US-8362032-B2 | Bicyclic derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-29 | — | — | US | claimed |
| EP-1720835-B1 | NOVEL GUANIDINYL-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AS EFFECTIVE PHOSPHODIESTERASE (PDE) 4 INHIBITORS | NYCOMED GMBH (DE) | 2012-12-12 | — | — | EP | claimed |
| US-8314125-B2 | Bicyclic derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-11-20 | — | — | US | claimed |
| EP-1891063-B1 | BICYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2012-07-25 | — | — | EP | claimed |
| EP-1888558-B1 | BICYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2011-10-05 | — | — | EP | claimed |
| US-7989481-B2 | Indane derivatives as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-02 | — | — | US | claimed |
| JP-4728259-B2 | — | — | 2011-07-20 | — | — | JP | claimed |
| WO-1999032466-A1 | SUBSTITUTED BENZENESULFONAMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE | NOVARTIS AG (CH) | 1999-07-01 | — | — | WO | claimed |
| WO-1999007672-A1 | DERIVATIVES OF 2,5- AND 3,5-DISUBSTITUTED ANILINES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-02-18 | — | — | WO | claimed |
| WO-1998047523-A1 | PEPTIDYL-2-AMINO-1-HYDROXYALKANESULFONIC ACID CYSTEINE PROTEASE INHIBITORS | CEPHALON INC. (US) | 1998-10-29 | — | — | WO | claimed |
| US-5663183-A | CEREBRAL DISORDERS | SYNTHELABO (FR) | 1997-09-02 | — | — | US | claimed |
| WO-1996033718-A1 | AGENT FOR SEVERE ACUTE PANCREATITIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-10-31 | — | — | WO | claimed |
| EP-0213006-B1 | DERIVATIVES OF 2,3-DIHYDRO-BENZOFURANE, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ADIR ET COMPAGNIE (FR) | 1989-01-25 | — | — | EP | claimed |
| EP-0213006-A1 | Derivatives of 2,3-dihydro-benzofurane, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1987-03-04 | — | — | EP | claimed |
| EP-0063826-B1 | 2-AMINO-BENZOIC-ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICINES OR INTERMEDIATES | Dr. Karl Thomae GmbH (DE) | 1984-12-05 | — | — | EP | claimed |
| EP-0063826-A2 | 2-Amino-benzoic-acid derivatives, their preparation and their use as medicines or intermediates | Dr. Karl Thomae GmbH (DE) | 1982-11-03 | — | — | EP | claimed |
| EP-0023569-A1 | Derivatives of carboxylic acids, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1981-02-11 | — | — | EP | claimed |