Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.41 |
| ▸ | BLM | P54132 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 3/20 | 0.41 |
| ▸ | CASP7 | P55210 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11557734 | 0.74 | HTR2A (0.39) | POLBALDH1A1MAPTTDP1KDM4E | |
| SCHEMBL10659166 | 0.72 | PPARA (0.37) | KMT2APOLBALDH1A1MEN1MAPT | |
| SCHEMBL11559592 | 0.71 | CYP17A1 (0.37) | KMT2AMEN1HSD17B10LMNAPTGS2 | |
| SCHEMBL11559271 | 0.71 | PTGS1 (0.32) | PTGS2PTGS1 | |
| SCHEMBL11559332 | 0.71 | ESR1 (0.42) | ALDH1A1MAPTHPGDPIK3CACASP3 | |
| SCHEMBL11560540 | 0.69 | PTGS1 (0.33) | HSD17B10THRBPTGS1PDE3BPDE3A | |
| SCHEMBL11558638 | 0.69 | MAPK14 (0.37) | POLBMAPTPDE3BPDE3A | |
| SCHEMBL11558732 | 0.68 | MAPT (0.42) | KMT2APOLBALDH1A1MEN1MAPT | |
| SCHEMBL2114343 | 0.61 | MAPT (1.00) | KMT2APOLBALDH1A1MEN1MAPT | |
| SCHEMBL5151124 | 0.60 | MAPT (0.52) | KMT2APOLBALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002666-A1 | 1,2-Benzisoxazolyloxy (or thio) acetic acids and related compounds, process for their preparation and medicines containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-11 | — | — | EP | disclosed |