Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 5/20 | 0.51 |
| ▸ | CA1 | P00915 | 5/20 | 0.51 |
| ▸ | CA2 | P00918 | 5/20 | 0.51 |
| ▸ | CA4 | P22748 | 5/20 | 0.51 |
| ▸ | CA6 | P23280 | 5/20 | 0.51 |
| ▸ | CA7 | P43166 | 5/20 | 0.51 |
| ▸ | CA9 | Q16790 | 5/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.51 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.51 |
| ▸ | CA5A | P35218 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.51 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.51 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 8/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11554290 | 0.91 | ALDH1A1 (0.51) | CA12CA1CA2CA4CA6 | |
| SCHEMBL11555873 | 0.91 | ALDH1A1 (0.46) | CA12CA1CA2CA4CA6 | |
| SCHEMBL11556950 | 0.88 | ALDH1A1 (0.44) | CA12CA1CA2CA4CA6 | |
| SCHEMBL11553213 | 0.81 | CISD1 (0.51) | CA12CA1CA2CA4CA6 | |
| SCHEMBL11557893 | 0.80 | CA1 (0.72) | CA12CA1CA2CA4CA6 | |
| SCHEMBL11554422 | 0.80 | ALDH1A1 (0.54) | CA12CA1CA2CA4CA6 | |
| Sulosemide SCHEMBL1818931 | 0.79 | ALDH1A1 (0.51) | CA12CA1CA2CA4CA6 | |
| Sulosemide SCHEMBL30704848 | 0.79 | ALDH1A1 (0.51) | CA12CA1CA2CA4CA6 | |
| Sulosemide SCHEMBL12815038 | 0.78 | ALDH1A1 (0.50) | CA12CA1CA2CA4CA6 | |
| SCHEMBL11226942 | 0.78 | ALDH1A1 (0.52) | CA12CA1CA2CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4161533-A | DIURETICS, SALURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-17 | — | — | US | claimed |
| US-4161533-A | DIURETICS, SALURETICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-17 | — | — | US | disclosed |