Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 5/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11561427 | 0.89 | CYP3A4 (0.40) | MAPTLMNATP53THRBCYP3A4 | |
| SCHEMBL11556588 | 0.88 | MAPT (0.38) | MAPTLMNATP53THRBCYP3A4 | |
| SCHEMBL11561106 | 0.86 | CYP3A4 (0.50) | MAPTLMNATP53THRBCYP3A4 | |
| SCHEMBL11556973 | 0.84 | MAPT (0.36) | MAPTLMNATP53THRBCYP3A4 | |
| SCHEMBL11559832 | 0.82 | KMT2A (0.40) | MAPTLMNATP53MEN1KMT2A | |
| SCHEMBL11560560 | 0.82 | MAPT (0.35) | MAPTLMNATP53THRBCYP3A4 | |
| SCHEMBL11566684 | 0.82 | KMT2A (0.34) | MAPTLMNATP53THRBCYP3A4 | |
| SCHEMBL11561703 | 0.82 | MAPT (0.39) | MAPTLMNATP53THRBCYP3A4 | |
| SCHEMBL11565924 | 0.81 | CYP3A4 (0.35) | MAPTLMNATP53THRBCYP3A4 | |
| SCHEMBL11565451 | 0.80 | MEN1 (0.34) | MAPTLMNATP53THRBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4165229-A | SUBSTITUTED THIADIAZOL-2-YLUREA | ELI LILLY AND COMPANY (US) | 1979-08-21 | — | — | US | disclosed |