Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.32 |
| ▸ | MEN1 | O00255 | 9/20 | 0.32 |
| ▸ | MAPT | P10636 | 6/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11489202 | 0.81 | THRB (0.31) | THRBMAPTTP53 | |
| SCHEMBL11558454 | 0.81 | MAPT (0.38) | THRBKMT2AMEN1MAPTLMNA | |
| SCHEMBL11564844 | 0.80 | MEN1 (0.39) | THRBKMT2AMEN1MAPTLMNA | |
| SCHEMBL11013664 | 0.80 | CYP3A4 (0.36) | THRBKMT2AMEN1MAPTLMNA | |
| SCHEMBL11486924 | 0.79 | CA1 (0.33) | KMT2ALMNAPOLBTP53 | |
| SCHEMBL11495768 | 0.78 | MAPT (0.32) | THRBKMT2AMEN1MAPTTP53 | |
| SCHEMBL11566684 | 0.78 | KMT2A (0.34) | THRBKMT2AMEN1MAPTLMNA | |
| SCHEMBL11486958 | 0.77 | CYP3A4 (0.32) | LMNA | |
| SCHEMBL11560945 | 0.76 | MAPT (0.39) | THRBKMT2AMEN1MAPTLMNA | |
| SCHEMBL11494717 | 0.75 | CA1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4165229-A | SUBSTITUTED THIADIAZOL-2-YLUREA | ELI LILLY AND COMPANY (US) | 1979-08-21 | — | — | US | disclosed |
| US-3972706-A | SUBSTITUTED THIADIAZOL-2-YL-UREAS | ELI LILLY AND COMPANY (US) | 1976-08-03 | — | — | US | disclosed |