SCHEMBL11564969

SCHEMBL11564969

CC(C)N1CCC(Nc2ccccc2)(C(=O)O)CC1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.49
ALDH1A1 P00352 2/20 0.48
CYP1A2 P05177 1/20 0.41
KMT2A Q03164 1/20 0.40
HRH3 Q9Y5N1 5/20 0.40
KCNH2 Q12809 2/20 0.40
CTSK P43235 1/20 0.40
TRPV4 Q9HBA0 1/20 0.40
PTPN11 Q06124 1/20 0.39
CHRM1 P11229 1/20 0.39
TSHR P16473 1/20 0.39
CYP2C19 P33261 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA4 P22748 1/20 0.39
CA5A P35218 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
CA13 Q8N1Q1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11564386 0.90 CYP2D6 (0.47) CYP2D6ALDH1A1KMT2AHRH3KCNH2
SCHEMBL27749328 0.87 OPRL1 (0.54) CYP2D6ALDH1A1
SCHEMBL11447549 0.87 CYP2D6 (0.45) CYP2D6ALDH1A1KMT2AHRH3KCNH2
Hydrochloric Acid SCHEMBL11565672 0.86 CYP2D6 (0.44) CYP2D6ALDH1A1KMT2AHRH3CTSK
Hydrochloric Acid SCHEMBL11793741 0.85 CYP2D6 (0.43) CYP2D6ALDH1A1KMT2AHRH3CTSK
SCHEMBL14492511 0.85 CYP2D6 (0.43) CYP2D6ALDH1A1KMT2AHRH3KCNH2
Hydrochloric Acid SCHEMBL11793742 0.85 CYP2D6 (0.43) CYP2D6ALDH1A1KMT2AHRH3CTSK
SCHEMBL11563510 0.83 OPRM1 (0.45) CYP2D6ALDH1A1KMT2AKCNH2
SCHEMBL7153039 0.80 CYP1A2 (0.53) CYP2D6ALDH1A1CYP1A2CTSKTSHR
Hydrochloric Acid SCHEMBL2991144 0.75 CYP1A2 (0.61) ALDH1A1CYP1A2CTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4179569-A ANALGESIC INTERMEDIATES JANSSEN PHARMACEUTICA N.V. (BE) 1979-12-18 US disclosed