Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HTR3B | O95264 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.49 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1243996 | 0.75 | KDM4E (0.59) | KDM4EHSD17B10ALDH1A1SLC6A4SCN7A | |
| SCHEMBL14198735 | 0.75 | SLC6A4 (0.56) | HTR3EHTR3BHTR2CSLC6A4HTR3A | |
| SCHEMBL5139469 | 0.75 | TSHR (0.66) | CYP1A2CYP3A4KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL3585730 | 0.75 | POLB (0.55) | CYP1A2CYP3A4KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL29756443 | 0.75 | CYP3A4 (0.55) | CYP1A2CYP3A4KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL2170401 | 0.75 | CYP3A4 (0.55) | CYP1A2CYP3A4KDM4EHSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6586965 | 0.74 | TSHR (0.64) | CYP1A2CYP3A4KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL92506 | 0.74 | L3MBTL1 (0.63) | KDM4EALDH1A1USP2HTTLMNA | |
| SCHEMBL3917010 | 0.74 | CXCR4 (0.57) | CYP1A2CYP3A4KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL14805320 | 0.73 | CYP1A2 (0.67) | CYP1A2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499144-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011058110-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2011-05-19 | — | — | WO | disclosed |