Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.44 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | GRM6 | O15303 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28791743 | 0.79 | HRH2 (0.41) | SIGMAR1BACE1MAPTHRH2TMEM97 | |
| SCHEMBL2985624 | 0.78 | NPFFR1 (0.62) | NPFFR1NPFFR2OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL5240984 | 0.77 | NPFFR1 (0.61) | NPFFR1NPFFR2OPRM1OPRD1OPRK1 | |
| SCHEMBL6045494 | 0.77 | NPFFR1 (0.61) | NPFFR1NPFFR2OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL11455282 | 0.77 | NPFFR1 (0.61) | NPFFR1NPFFR2OPRM1OPRD1OPRK1 | |
| SCHEMBL6045741 | 0.77 | SMN1; SMN2 (0.55) | OPRM1SIGMAR1BACE1MAPTCA12 | |
| SCHEMBL11567766 | 0.74 | CA12 (0.42) | NPFFR1NPFFR2OPRM1OPRD1OPRK1 | |
| SCHEMBL16862197 | 0.73 | CYP2D6 (0.51) | ALDH1A1CYP2D6BACE1MAPT | |
| SCHEMBL3171094 | 0.73 | NPFFR1 (0.60) | NPFFR1NPFFR2OPRM1OPRD1OPRK1 | |
| SCHEMBL27538171 | 0.73 | MAPT (0.43) | OPRM1SIGMAR1BACE1MAPTTMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4179569-A | ANALGESIC INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-12-18 | — | — | US | disclosed |