Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR1 | Q9GZQ6 | 6/20 | 0.60 |
| ▸ | NPFFR2 | Q9Y5X5 | 6/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.60 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL654615 | 0.93 | OPRM1 (0.53) | NPFFR1NPFFR2OPRK1OPRM1OPRD1 | |
| SCHEMBL11566839 | 0.92 | OPRM1 (0.53) | NPFFR1NPFFR2OPRK1OPRM1OPRD1 | |
| SCHEMBL11559495 | 0.92 | CYP2D6 (0.57) | NPFFR1NPFFR2OPRK1OPRM1OPRD1 | |
| SCHEMBL2985764 | 0.89 | CYP2D6 (0.60) | NPFFR1NPFFR2OPRK1OPRM1OPRD1 | |
| SCHEMBL11562813 | 0.89 | NPFFR1 (0.60) | NPFFR1NPFFR2OPRK1OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL11455428 | 0.88 | CYP2D6 (0.58) | NPFFR1NPFFR2OPRK1OPRM1OPRD1 | |
| SCHEMBL9737959 | 0.87 | CA12 (0.62) | NPFFR1NPFFR2OPRK1OPRM1OPRD1 | |
| SCHEMBL11561939 | 0.87 | NPFFR1 (0.53) | NPFFR1NPFFR2OPRK1OPRM1OPRD1 | |
| SCHEMBL2985624 | 0.86 | NPFFR1 (0.62) | NPFFR1NPFFR2OPRK1OPRM1OPRD1 | |
| SCHEMBL11561860 | 0.86 | UBE2M (0.55) | NPFFR1NPFFR2OPRK1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110577489-B | Synthetic method of narcotic analgesic | 宜昌人福药业有限责任公司 | 2023-02-21 | — | — | CN | disclosed |
| EP-3643704-B1 | NEW INTERMEDIATES FOR THE PREPARATION OF REMIFENTANIL HYDROCHLORIDE | HAMELN PHARMA GMBH (DE) | 2020-12-16 | — | — | EP | disclosed |
| US-10844014-B2 | Intermediates for the preparation of remifentanil hydrochloride | HAMELN PHARMA GMBH (DE) | 2020-11-24 | — | — | US | disclosed |
| US-20200352917-A1 | MEDICATED SPRAY FOR TREATMENT OF SUBSTANCE ABUSE, OVERDOSE, ADDICTION AND IMPULSE CONTROL DISORDERS | GOOBERMAN LANCE L (US) | 2020-11-12 | — | — | US | disclosed |
| US-20200131127-A1 | INTERMEDIATES FOR THE PREPARATION OF REMIFENTANIL HYDROCHLORIDE | HAMELN PHARMA PLUS GMBH (DE) | 2020-04-30 | — | — | US | disclosed |
| EP-3643704-A1 | NEW INTERMEDIATES FOR THE PREPARATION OF REMIFENTANIL HYDROCHLORIDE | hameln pharma plus gmbh (DE) | 2020-04-29 | — | — | EP | disclosed |
| CN-110577489-A | Synthetic method of narcotic analgesic | 宜昌人福药业有限责任公司 | 2019-12-17 | — | — | CN | disclosed |
| EP-3199523-A1 | THE NEW PROCESS FOR PRODUCING N-PHENYL-N-(4-PIPERIDINYL) AMIDE DERIVATIVES SUCH AS REMIFENTANIL AND CARFENTANIL | Bioka s. r.o. (SK) | 2017-08-02 | — | — | EP | disclosed |
| US-9278929-B1 | Synthesis of intermediate anilino methyl esters used in the production of synthetic opioid analgesics | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2016-03-08 | — | — | US | disclosed |
| US-9278929-B1 | Synthesis of intermediate anilino methyl esters used in the production of synthetic opioid analgesics | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2016-03-08 | — | — | US | disclosed |
| US-4208418-A | ANTIARRHYTHMIA | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-06-17 | — | — | US | disclosed |
| US-4198411-A | ANTIARRHYTHMIC AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-04-15 | — | — | US | disclosed |
| US-4197303-A | ANTIARRHYTHMIA AGENTS, ALKOXYCARBONYL ON 4-POSITION OF PIPERIDINE | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-04-08 | — | — | US | disclosed |
| US-4197304-A | ANTIARRHYTHMIA AGENTS, N-PYRIDINYL-N-(4-ALKYLPIPERIDINYL)THIENYLACETAMIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-04-08 | — | — | US | disclosed |
| US-4196210-A | ANTIARRHYTHMIA AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-04-01 | — | — | US | disclosed |
| US-4179569-A | ANALGESIC INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-12-18 | — | — | US | disclosed |
| US-4157393-A | ANTIARRHYTHMIA AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-06-05 | — | — | US | disclosed |
| US-4151286-A | ANTIARRHYTHMIC AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-04-24 | — | — | US | disclosed |
| US-4126689-A | ANTIARRHYTHMIA | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-11-21 | — | — | US | disclosed |
| US-3998834-A | ANALGESICS | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10844014-B2 | Intermediates for the preparation of remifentanil hydrochloride | OPRK1, OPRM1, OPRD1 | NPFFR1 1217/4885NPFFR2 969/4885OPRK1 1/4885 |
| US-20200131127-A1 | INTERMEDIATES FOR THE PREPARATION OF REMIFENTANIL HYDROCHLORIDE | OPRK1, OPRM1, OPRD1 | NPFFR1 1217/4885NPFFR2 969/4885OPRK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.