Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | IL18 | Q14116 | 1/20 | 0.48 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2474521 | 0.91 | GAA (0.48) | AKR1C3AKR1C2AKR1C1PTGS1MAPT | |
| SCHEMBL6649963 | 0.88 | PTGS1 (0.51) | AKR1C3AKR1C2AKR1C1PTGS1PARP15 | |
| SCHEMBL11563036 | 0.80 | AKR1C3 (0.54) | AKR1C3AKR1C2AKR1C1PTGS1PARP10 | |
| SCHEMBL11640849 | 0.80 | PARP15 (0.53) | AKR1C3AKR1C2PTGS1PARP15PARP10 | |
| SCHEMBL30372489 | 0.79 | AKR1C3 (0.47) | AKR1C3AKR1C2AKR1C1PTGS1MAPT | |
| SCHEMBL7387904 | 0.78 | SLC6A3 (0.47) | MAPTPOLBLMNAKDM4EL3MBTL1 | |
| SCHEMBL1741211 | 0.78 | AKR1C3 (0.58) | AKR1C3AKR1C2AKR1C1PTGS1PARP10 | |
| SCHEMBL28689101 | 0.77 | HTT (0.45) | MAPTKDM4EMEN1KMT2AFNTA | |
| SCHEMBL1574429 | 0.77 | AKR1C3 (0.58) | AKR1C3AKR1C2AKR1C1PTGS1POLB | |
| SCHEMBL25253804 | 0.76 | GSK3B (0.46) | MAPTPOLBKDM4EL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4168385-A | LOWERING OF STEROL AND TRIGLYCERIDE SERUM LEVELS | AMERICAN CYANAMID COMPANY (US) | 1979-09-18 | — | — | US | disclosed |
| US-4125729-A | Hypolipemic α-aryloxy para substituted phenyl acetic acid compounds | AMERICAN CYANAMID COMPANY (US) | 1978-11-14 | — | — | US | disclosed |