Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.61 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.61 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11563434 | 0.90 | OPRM1 (0.60) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| SCHEMBL11569033 | 0.88 | OPRM1 (0.78) | OPRM1OPRD1OPRK1 | |
| SCHEMBL11796741 | 0.87 | OPRM1 (0.77) | OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL11567839 | 0.87 | OPRM1 (0.69) | OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL11569081 | 0.86 | OPRM1 (0.76) | OPRM1OPRD1OPRK1 | |
| SCHEMBL9153525 | 0.83 | OPRM1 (0.53) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| Hydrochloric Acid SCHEMBL11565087 | 0.80 | OPRM1 (0.76) | OPRM1OPRD1OPRK1SLC22A1ABCB1 | |
| SCHEMBL3303683 | 0.80 | OPRM1 (0.80) | OPRM1OPRD1OPRK1 | |
| SCHEMBL11564033 | 0.79 | OPRM1 (0.71) | OPRM1OPRD1OPRK1 | |
| SCHEMBL821488 | 0.79 | OPRM1 (0.78) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4179569-A | ANALGESIC INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-12-18 | — | — | US | disclosed |
| US-3998834-A | ANALGESICS | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-12-21 | — | — | US | disclosed |