Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11561171 | 0.83 | ALDH1A1 (0.51) | ALDH1A1MAPTLMNAPOLBL3MBTL1 | |
| Bromide SCHEMBL11567154 | 0.83 | ALDH1A1 (0.51) | ALDH1A1MAPTLMNAPOLBL3MBTL1 | |
| Bromide SCHEMBL11559548 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MAPTLMNAPOLBL3MBTL1 | |
| Bromide SCHEMBL11567033 | 0.80 | ALDH1A1 (0.48) | ALDH1A1MAPTLMNAPOLBL3MBTL1 | |
| Bromide SCHEMBL11558243 | 0.79 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNAPOLBL3MBTL1 | |
| Bromide SCHEMBL11558187 | 0.78 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNAPOLBL3MBTL1 | |
| Bromide SCHEMBL9328086 | 0.77 | KMT2A (0.35) | ALDH1A1MAPTCYP2C19NPSR1MEN1 | |
| Bromide SCHEMBL11561013 | 0.77 | ALDH1A1 (0.45) | ALDH1A1MAPTLMNAPOLBL3MBTL1 | |
| Bromide SCHEMBL11564106 | 0.77 | ALDH1A1 (0.46) | ALDH1A1MAPTLMNAPOLBL3MBTL1 | |
| Bromide SCHEMBL4384622 | 0.76 | KMT2A (0.33) | ALDH1A1CYP2C19NPSR1KMT2ACTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4151280-A | ANTIALLERGENS | ROUSSEL UCLAF (FR) | 1979-04-24 | — | — | US | disclosed |