Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11559553 | 0.87 | MEN1 (0.47) | MEN1KMT2ANPSR1ALDH1A1GSK3A | |
| Bromide SCHEMBL11561174 | 0.87 | MEN1 (0.49) | MEN1KMT2ANPSR1ALDH1A1GSK3A | |
| Bromide SCHEMBL11558192 | 0.85 | MEN1 (0.45) | MEN1KMT2ANPSR1ALDH1A1LMNA | |
| Bromide SCHEMBL11561016 | 0.83 | MEN1 (0.44) | MEN1KMT2ANPSR1ALDH1A1LMNA | |
| Bromide SCHEMBL11567035 | 0.82 | MEN1 (0.51) | MEN1KMT2ANPSR1ALDH1A1LMNA | |
| Bromide SCHEMBL11565948 | 0.82 | NPSR1 (0.47) | MEN1KMT2ANPSR1ALDH1A1GSK3A | |
| Bromide SCHEMBL11558248 | 0.81 | NPSR1 (0.46) | MEN1KMT2ANPSR1ALDH1A1LMNA | |
| Bromide SCHEMBL11564109 | 0.79 | ALDH1A1 (0.47) | MEN1KMT2ANPSR1ALDH1A1LMNA | |
| SCHEMBL17792927 | 0.78 | POLB (0.42) | MEN1KMT2AALDH1A1TDP1MAPT | |
| Hydrochloric Acid SCHEMBL3854539 | 0.74 | MAPT (0.48) | MEN1KMT2AALDH1A1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4151280-A | ANTIALLERGENS | ROUSSEL UCLAF (FR) | 1979-04-24 | — | — | US | disclosed |