Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | DRD1 | P21728 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046280 | 0.88 | TAAR1 (0.48) | HTR2ASLC6A3SLC6A2SLC6A4CHRM2 | |
| Bromide SCHEMBL29799767 | 0.86 | TAAR1 (0.46) | HTR2ASLC6A3SLC6A2SLC6A4CHRM2 | |
| SCHEMBL13383171 | 0.74 | CYP1A2 (0.38) | HTR2AADRA2AADRA2BCYP2D6 | |
| SCHEMBL11249849 | 0.74 | HTR2A (0.42) | HTR2ASLC6A3SLC6A2SLC6A4CNR1 | |
| SCHEMBL11258389 | 0.74 | HTR2A (0.42) | HTR2ASLC6A3SLC6A2SLC6A4CNR1 | |
| SCHEMBL9533613 | 0.74 | HTR2A (1.00) | HTR2ASLC6A3SLC6A2SLC6A4CHRM2 | |
| SCHEMBL9531164 | 0.74 | HTR2A (1.00) | HTR2ASLC6A3SLC6A2SLC6A4CHRM2 | |
| SCHEMBL9528231 | 0.74 | HTR2A (1.00) | HTR2ASLC6A3SLC6A2SLC6A4CHRM2 | |
| SCHEMBL17802362 | 0.74 | HTR2A (0.63) | HTR2ASLC6A3SLC6A2SLC6A4CHRM2 | |
| SCHEMBL21322418 | 0.72 | TAAR1 (0.56) | HTR2ASLC6A3SLC6A2CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000322-A1 | Compounds having an anti-depressive or tranquilizing activity, pharmaceutical compositions containing them, and processes and intermediates for their preparation | Astra Läkemedel Aktiebolag (SE) | 1979-01-10 | — | — | EP | disclosed |