Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC26A6 | Q9BXS9 | 14/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6293949 | 0.84 | KDM4E (0.46) | KDM4EALDH1A1HPGDCASP1GAA | |
| SCHEMBL11820968 | 0.80 | PDE5A (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2SLC26A6 | |
| SCHEMBL11818968 | 0.78 | KDM4E (0.49) | KDM4EALDH1A1HPGDCASP1GAA | |
| SCHEMBL11819884 | 0.77 | KDM4E (0.48) | KDM4EALDH1A1HPGDCASP1GAA | |
| SCHEMBL5961528 | 0.77 | KMT2A (0.55) | KDM4EALDH1A1HPGDCASP1GAA | |
| SCHEMBL18320719 | 0.66 | KDM4E (0.62) | KDM4EALDH1A1HPGDCASP1GAA | |
| SCHEMBL20875396 | 0.66 | ALDH1A1 (0.63) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL18320759 | 0.65 | KDM4E (0.61) | KDM4EALDH1A1HPGDCASP1GAA | |
| SCHEMBL11585740 | 0.64 | MAPT (0.48) | HPGDSLC26A6TP53 | |
| SCHEMBL5961479 | 0.64 | HPGD (0.52) | KDM4EALDH1A1HPGDCASP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4161525-A | Process of treating proliferative skin diseases with indole derivatives | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1979-07-17 | — | — | US | disclosed |
| US-4144332-A | USING AN ANILINO-NICOTINIC ACID | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1979-03-13 | — | — | US | disclosed |
| US-4141976-A | XANTHINES OR THIOXANTHINES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1979-02-27 | — | — | US | disclosed |
| US-4107306-A | OXO-BENZOTHIOPHENES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1978-08-15 | — | — | US | disclosed |
| US-4034087-A | TREATING PROLIFERATIVE SKIN DISEASES WITH 4-BENZYL-2-IMIDAZOLIDONES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1977-07-05 | — | — | US | disclosed |