Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 13/20 | 0.68 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11465917 | 0.78 | CYP19A1 (0.68) | CYP19A1CYP17A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL11465747 | 0.76 | CYP19A1 (0.78) | CYP19A1CYP17A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL6024563 | 0.74 | CYP19A1 (0.82) | CYP19A1CYP17A1CYP3A4CYP2D6MEN1 | |
| SCHEMBL11482329 | 0.74 | CYP19A1 (0.70) | CYP19A1CYP17A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL11474401 | 0.74 | CYP19A1 (0.70) | CYP19A1CYP17A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL11481266 | 0.72 | CYP19A1 (0.72) | CYP19A1CYP17A1CYP3A4CYP2D6CYP1A2 | |
| SCHEMBL11567844 | 0.71 | CYP19A1 (0.32) | CYP19A1OPRK1NPSR1 | |
| Lombazole SCHEMBL829388 | 0.70 | CYP17A1 (0.73) | CYP19A1CYP17A1CYP3A4MEN1NR1I2 | |
| SCHEMBL11465924 | 0.70 | CYP19A1 (0.63) | CYP19A1CYP17A1CYP3A4CYP2D6MEN1 | |
| SCHEMBL11463607 | 0.70 | CYP19A1 (0.63) | CYP19A1CYP17A1CYP3A4CYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003796-A1 | Substituted diphenylmethyl-imidazoles, their preparation and medicaments containing them | BAYER AG (DE) | 1979-09-05 | — | — | EP | disclosed |