Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSH | P09668 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.33 |
| ▸ | CCR1 | P32246 | 2/20 | 0.33 |
| ▸ | CCR5 | P51681 | 2/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2025555 | 0.98 | KMT2A (0.44) | KMT2AOPRK1GAAKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11566738 | 0.96 | KMT2A (0.43) | KMT2AOPRK1GAAKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11567075 | 0.96 | KMT2A (0.43) | KMT2AOPRK1GAAKDM4EALDH1A1 | |
| SCHEMBL11567724 | 0.96 | KMT2A (0.43) | KMT2AOPRK1GAAKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11567780 | 0.96 | KMT2A (0.43) | KMT2AOPRK1GAAKDM4EALDH1A1 | |
| SCHEMBL11565911 | 0.91 | KMT2A (0.40) | KMT2AOPRK1GAAKDM4EALDH1A1 | |
| SCHEMBL11564820 | 0.91 | KMT2A (0.40) | KMT2AOPRK1GAAKDM4EALDH1A1 | |
| SCHEMBL11560640 | 0.91 | KMT2A (0.40) | KMT2AOPRK1GAAKDM4EALDH1A1 | |
| SCHEMBL11565819 | 0.91 | KMT2A (0.40) | KMT2AOPRK1GAAKDM4EALDH1A1 | |
| SCHEMBL11564300 | 0.91 | KMT2A (0.40) | KMT2AOPRK1GAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4169092-A | Transition metal-naphthyridine chemical complexes | BAYER JOHN W | 1979-09-25 | — | — | US | disclosed |