Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10137023 | 0.81 | POLB (0.54) | SMN1; SMN2KDM4EPOLBLMNAGAA | |
| SCHEMBL16202971 | 0.76 | KMT2A (0.65) | SMN1; SMN2KDM4EHPGDPOLBLMNA | |
| SCHEMBL11723587 | 0.76 | GAA (0.45) | SMN1; SMN2KDM4EPOLBLMNAGAA | |
| SCHEMBL11723616 | 0.76 | GAA (0.45) | SMN1; SMN2KDM4EPOLBLMNAGAA | |
| SCHEMBL13846427 | 0.72 | MAPT (0.56) | SMN1; SMN2KDM4EHPGDPOLBLMNA | |
| SCHEMBL17505927 | 0.69 | GAA (0.55) | SMN1; SMN2KDM4EHPGDLMNAGAA | |
| SCHEMBL29058297 | 0.69 | GAA (0.55) | SMN1; SMN2KDM4EHPGDLMNAGAA | |
| SCHEMBL17505924 | 0.69 | GAA (0.55) | SMN1; SMN2KDM4EHPGDLMNAGAA | |
| SCHEMBL30532029 | 0.69 | GAA (0.55) | SMN1; SMN2KDM4EHPGDLMNAGAA | |
| SCHEMBL4938228 | 0.68 | KMT2A (0.62) | SMN1; SMN2HPGDPOLBLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002231-A1 | 1-N-aryl-1,4-dihydropyridines, process for their preparation and their pharmaceutical application | BAYER AG (DE) | 1979-06-13 | — | — | EP | disclosed |