Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | PLEC | Q15149 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27450524 | 0.90 | ALDH1A1 (0.47) | MAPTKDM4EHPGDALDH1A1GAA | |
| SCHEMBL8960208 | 0.82 | MAPT (0.61) | MAPTKDM4EHPGDALDH1A1GAA | |
| SCHEMBL8281122 | 0.81 | HDAC1 (0.41) | MAPTKDM4EHPGDALDH1A1GAA | |
| SCHEMBL28632380 | 0.79 | MAPT (0.43) | MAPTKDM4EHPGDALDH1A1GAA | |
| SCHEMBL10920479 | 0.78 | ALDH1A1 (0.65) | MAPTALDH1A1GAAHSD17B10RAB9A | |
| SCHEMBL5518380 | 0.77 | KDM4E (0.43) | MAPTKDM4EHPGDALDH1A1GAA | |
| SCHEMBL2003577 | 0.76 | KMT2A (0.52) | MAPTKDM4EHPGDALDH1A1HSD17B10 | |
| SCHEMBL10966054 | 0.76 | ALDH1A1 (0.55) | MAPTKDM4EHPGDALDH1A1GAA | |
| SCHEMBL11150129 | 0.75 | MEN1 (0.50) | MAPTKDM4EHPGDALDH1A1RAB9A | |
| SCHEMBL20447579 | 0.74 | GSK3B (0.48) | MAPTKDM4EHPGDALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004611-A1 | Process for the preparation of acetoacetylaryl amides | CIBA-GEIGY AG (CH) | 1979-10-17 | — | — | EP | disclosed |